The GFF has supported Guinea’s priorities to promote better health outcomes for all women, children and adolescents. The focus is placed on closing service delivery gaps in regions with lagging health outcomes and resources, including by investing more to equip the frontlines with medical commodities and community health workers.

Under the government’s leadership, Guinea's investment case also prioritizes a series of health systems and financing reforms such as strengthening results-based financing and improve spending efficiency; rolling out a streamlined health management information system, and modernizing the civil registration and vital statistics systems. To align resources and ensure accountability, the GFF supports the government to coordinate partners, engage civil society organizations in the implementation and monitoring of the investment case and promote better health management information systems.